Mutated events in Fallout 76 are some of the most challenging encounters in Appalachia, and having the right arsenal can make all the difference. Whether you’re teaming up with friends or going solo, knowing which weapons perform best can save you both time and caps.

1. Gauss Rifle

The Gauss Rifle remains a top choice for high-damage output. Its charged shots can quickly take down tougher mutated enemies, especially during events like Feral Ghoul Swarms or Scorched Behemoths. While it has a slower fire rate, each hit packs a punch, making it ideal for players who prefer precision over spray-and-pray tactics. If you’re low on resources, keep an eye on vendors where you might buy Fallout 76 caps to trade for ammo or mods to enhance this weapon.

2. Combat Shotgun

For close-quarters encounters, the Combat Shotgun shines. Mutated events often feature waves of enemies, and the shotgun’s spread allows you to hit multiple targets at once. It’s especially effective against melee-oriented foes. Combining this weapon with chems and armor with damage resistance can make you nearly unstoppable during an intense mutated outbreak.

3. Handmade Rifle

Versatility is the Handmade Rifle’s strong suit. It offers both semi-auto and burst fire modes, which can adapt to different combat situations. When you’re hunting down mutated creatures that move unpredictably, this weapon’s accuracy and moderate fire rate give you a reliable edge. Additionally, upgrading its mods can be worthwhile; sometimes it’s more cost-effective to buy Fallout 76 caps and purchase rare components than to farm them manually.

4. Minigun

If you’re feeling confident and want to clear hordes quickly, the Minigun is a great choice. While it consumes ammo at a rapid pace, its sheer firepower can turn the tide of even the toughest mutated events. Pair it with a sturdy power armor set, and you’ll be able to hold your ground while dealing massive damage.

5. Plasma Caster

For players who enjoy energy weapons, the Plasma Caster provides excellent damage and a bit of crowd control. Its shots can stagger enemies, giving you breathing room during hectic fights. Though ammo can be scarce, it’s often worth saving caps to ensure you have enough for the next big event.

Final Tips

Beyond choosing the right weapons, always consider your mods, ammo stockpile, and teamwork if you’re in a group. Mutated events can be unpredictable, and having a balanced setup will make you much more resilient. If you ever find yourself short on essentials, it’s not uncommon to buy Fallout 76 caps to quickly get the gear you need, though careful planning can often save you from overspending.

With the right weapons in hand and a solid strategy, mutated events can become one of the most rewarding challenges in Fallout 76. Experiment with different combinations to find what fits your playstyle best, and you’ll be well-prepared for any outbreak Appalachia throws your way.